Sumoylation in gene regulation, human disease, and therapeutic action
نویسندگان
چکیده
منابع مشابه
Sumoylation in gene regulation, human disease, and therapeutic action
Similar to ubiquitination, sumoylation covalently attaches a small ubiquitin-like modifier (SUMO) protein (92-97 amino acids) to the ε-amino group of a lysine residue. This is quite different from the classically defined post-translational modifications, such as phosphorylation, acetylation, and methylation, which typically add a small chemical group to the targeted residue. Sumoylation has bee...
متن کاملSumoylation and regulation of cardiac gene expression.
Sumoylation is a posttranslational modification process in which SUMO proteins are covalently and reversibly conjugated to their targets via enzymatic cascade reactions. Since the discovery of SUMO-1 in 1996, the SUMO pathway has garnered increased attention due to its role in a number of important biological activities such as cell cycle progression, epigenetic modulation, signal transduction,...
متن کاملGene Regulation: Histones, HDACs, PARPs, Ubiquitination & Sumoylation
Ubiquitination & Sumoylation C e l l C y c l e & D N A T r a n s a c t i o n s In eukaryotes, the several meters long genomic DNA needs to be packed into chromosomes with a diameter of only several hundred micrometers. This is achieved through an elaborated scheme of packaging that starts with the formation of nucleosomes from DNA winding around an octamer core of histones H2A/H2B/H3/H4, foll...
متن کاملMechanisms, regulation and consequences of protein SUMOylation.
The post-translational modification SUMOylation is a major regulator of protein function that plays an important role in a wide range of cellular processes. SUMOylation involves the covalent attachment of a member of the SUMO (small ubiquitin-like modifier) family of proteins to lysine residues in specific target proteins via an enzymatic cascade analogous to, but distinct from, the ubiquitinat...
متن کاملTHERAPEUTIC EFFECTS OF LASER PHOTOCOAGULATION AND VITRECTOMY IN EALES\'DISEASE
Eales' disease is an idiopathic obliterative retinal vasculopathy that is treated with laser photocoagulation, and/or vitrectomy. In order to determine visual outcomes and regression of retinal neovascularization following scattered peripheral retinal photocoagulation, and/or vitrectomy in cases with Eales' disease, we did a retrospective study of the records of these patients treated in La...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: F1000Prime Reports
سال: 2013
ISSN: 2051-7599
DOI: 10.12703/p5-45